Pharmacometrics: Analysis of in-progress or completed clinical trials, focussing on effect size and robustness of multiple outcomes rather than hypothesis testing.
Pharmacokinetic
modeling: Mixed-effects (NONMEM) methods
analysis
of routine or complicated pharmacokinetic clinical/preclinical issues
such as:
• Linear vs. nonlinear absorption
• Saturable elimination
• Metabolite kinetics
• Sparse data
Pharmacodynamic modeling: Development and analysis of pharmacodynamic models (both direct and indirect) to develop dosing strategies and to evaluate success of clinical trials.
Regression models, other statistics: Linear, non-linear, and logistic regression analysis of sparse data, unbalanced samples, or missing data, using mixed-effects approaches when appropriate.
Clinical trial simulation: Development of dosing and sampling regimens for clinical trials based on available preclinical and clinical data. Simulation of outcomes of clinical trials to evaluate trial design.